Antimycotics (antifungal drugs)

Cytochrome P450

Azoles such as itraconazole and voriconazole inhibit CYP3A4.

• Drug metabolismPharmacokineticsNot written yetPhase I reactions, most of them by CYP enzymes.
• Drug interactions at pharmacokinetic levelPharmacodynamicsNot written yetInducers lower other drugs’ levels; inhibitors raise them.
• Factors on the part of the body influencing the kinetics and the action of the drugsPharmacodynamicsNot written yetGene variants make some people slow or fast metabolisers.
• Antituberculosis drugs. Antileprosy drugsAntimicrobials and chemotherapeuticsRifampicin is a strong inducer: it can make the pill or warfarin fail.
• Antiepileptic drugs (AEDs)Central and peripheral nervous systemNot written yetCarbamazepine and phenytoin are inducers.
• Macrolides and ketolides (50S inhibitors)Antimicrobials and chemotherapeuticsClarithromycin and erythromycin inhibit CYP3A4.
• AnticoagulantsHematologic drugsNot written yetDrugs that inhibit or induce CYP2C9, such as fluconazole or rifampicin, shift warfarin’s effect.
• Antidepressants: types, mechanism of action, clinical effects, adverse effects, indications, and monitoringPsychiatryFluoxetine and paroxetine inhibit CYP2D6, raising the levels of other drugs it breaks down.